Application of 954255-04-0,Some common heterocyclic compound, 954255-04-0, name is 5,6-Difluoroindoline, molecular formula is C8H7F2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5,6-difluoro-indoline 0.40g (2.58mmol),3,5-dimethoxybromobenzene 0.58 g (2.71 mmol),3% molar amount of Pd(OAc) 2 (17 mg),6% molar amount of P(t-Bu)3.HBF4 (45 mg),Sodium tert-butoxide (0.50 g, 5.16 mmol) was added to 40 mL of toluene.Heating at 110 C for 12 h,filter,The filtrate is depressurized to remove the solvent.Column chromatography (PE: CH2Cl2 = 5:1) gave 0.45 g of white crystals.The yield was 60%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Difluoroindoline, its application will become more common.