In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 32692-19-6 as follows. name: 5-Nitroindoline
EXAMPLE 10 Preparation of 1-benzyl-5-nitro-2,3-dihydro-1H-indole Under the presence of nitrogen, 5-nitroindolin (50 mg, 0.30 mmol) was dissolved in dimethylformamide (2 ml) at room temperature and benzyl bromide (0.04 ml. 0.34 mmol) and potassium carbonate (0.126 ml, 3.0 equivalent) were added and stirred at room temperature for 48 hours. After completing the reaction, water and ethyl acetate (respectively 5 ml) were added to separate layers, washed with brine, dried over anhydrous magnesium sulfate, and concentrated. Finally, the residue was purified through flash column chromatography (an eluent: ethyl acetate/n-hexane=1/4, v/v). As a result, the present compound (45 mg, productive yield 58%) was obtained. 1H-NMR (400 MHz, CDCl3) delta3.10 (t, J=9 Hz, 2H), 3.65 (t, J=9 Hz, 2H), 4.45 (s, 2H), 6.35 (d, J=9 Hz, 1H), 7.25-7.45 (m, 5H), 7.90 (s, 1H), 8.05-8.10 (m, 1H) melting point: 73~74 C.
According to the analysis of related databases, 32692-19-6, the application of this compound in the production field has become more and more popular.