Reference of 7477-63-6, The chemical industry reduces the impact on the environment during synthesis 7477-63-6, name is 7-Chloroisatin, I believe this compound will play a more active role in future production and life.
General procedure: (Table 3, Entry 1): beta-Cyclodextrin (1.0 mmol) was dissolved in water (15 mL) by warming to 50-55 OC until a clear solution was formed. Then, isatin (1.0 mmol) dissolved in methanol (0.5 mL) was added followed by semicarbazide (1.0 mmol) and the mixture was stirred at 50-55 OC until the reaction was complete (as monitored by TLC). After completion of the reaction, mixture was cooled to room temperature and beta-cyclodextrin was filtered. The aqueous layer was extracted with ethyl acetate (3 x 10 ml). The combined organic layers were extracted with water, saturated brine solution and dried over anhydrous Na2SO4. The combined organic layers were evaporated under reduced pressure and the resulting crude product was purified by column chromatography by using ethyl acetate and hexane (4:6) as eluent. The aqueous layer was cooled to 5 OC to recover beta-CD (Table 1). The product was confirmed by IR, 1H 13C NMR, mass spectra.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Chloroisatin, other downstream synthetic routes, hurry up and to see.