Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., SDS of cas: 5332-26-3
The pure compound 5 (40 g, 94 mmol) was dissolved in anhydrous tetrahydrofuran (400 ml).Nitrogen replacement,Dry ice acetone cooled to -78 degrees,Slowly add tetrahydrofuran solution of sodium hexamethyldisilazide(112.8 mmol, the concentration of sodium hexamethyldisilazide is 2 mol/L),After completion of the dropwise addition, the system was stirred at -78C for 1 hour;Compound 13 (108 mmol) was dissolved in 400 ml anhydrous tetrahydrofuran (THF).The above system was slowly dropped through a constant pressure funnel.Control the dropping temperature below -70 degrees,After the addition was completed, the reaction was kept stirring at -78 degrees for 3 hours.It is naturally warmed to room temperature and stirred overnight.TLC showed that the starting material was completely reacted. The reaction was quenched with 500 ml of saturated aqueous ammonium chloride solution. The solvent tetrahydrofuran was removed by rotary evaporation. The residue was extracted three times with ethyl acetate (200 ml each time) and the combined organic phases were washed with saturated brine. Sodium sulphate was dried, filtered and spin-dried to obtain crude compound 6 and purified by column to obtain pure compound 6 (43 g) in a yield (78.24%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.