Reference of 3484-35-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3484-35-3, name is 5-Methylindolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
3-Methylindole-2-carbaldehyde was prepared as described in the literature: 1) David W. M. Benzies, Pilar Matinez Fresneda and R. Alan Jones, Synthetic Communications, 16 (14), 1799-1807 (1986) and 2) Chatterjee, A. and Biswas, K. M., J. Org. Chem., 1973, 38,4002. A mixture of 5-methyl-2-oxindole (59 mg), 3-methylindole-2-carbaldehyde (56 mg) and piperidine (30 mg) in ethanol (1 mL) was heated in a sealed tube at 90 C. for overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven for overnight to give 72 mg (74% yield) of 5-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one. 1H NMR (360 MHz, DMSO-d6) 13.03 (s, br, 1H, NH), 10.88 (s, br, 1H, NH), 7.84 (s, 1H, vinyl), 7.71 (s, br, 1H), 6.62 (d, J=8 Hz, 1H), 7.48 (d, J=8 Hz, 7.26 (t, J=7 Hz, 1H), 7.06 (t, J=7 Hz, 1H), 7.0 (d, J=8 Hz, 1H), 6.78 (d, J=8 Hz, 1H), 2.59 (s, 3H, CH3), 2.32 (s, 3H, CH3). MS m/z 289 [M+1]+.
The synthetic route of 5-Methylindolin-2-one has been constantly updated, and we look forward to future research findings.