Application of 3485-84-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3485-84-5, name is N-Vinylphthalimide belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure: In a sealed tube under argon atmosphere, were introducedcompound 4 (4.74 g, 20 mmol), DMF (20 mL), triethylamine(11.16 mL, 80 mmol), palladium diacetate (225 mg, 1 mmol), tri(otolyl)-phosphine (609 mg, 2 mmol) and N-vinylphthalimide (5.20 g,30 mmol). The mixturewas stirred at 110 C for 3 h and hydrolyzed.The formed solid was solubilized in CH2Cl2, washed with water andbrine, dried over MgSO4 and evaporated under reduced pressure.The crude productwas recrystallized from acetonitrile to afford 7 asa white solid (91% yield); Mp 199-200 C; 1H NMR (300 MHz,CDCl3):delta 8.49 (d, 1H, 15 Hz), 8.25 (d, 1H, 15 Hz), 8.00 (d, 1H, 9.0 Hz),7.92 (m, 2H), 7.81 (d, 1H, 7.8 Hz), 7.76 (m, 2H), 7.65 (d, 1H, 7.8 Hz),7.38 (t, 1H, 7.8 Hz), 6.96 (d, 1H, 9.0 Hz), 4.23 (s, 3H); IR (upsilon, cm-1, KBr):1715 (C=O); MS (APCI, pos. 30 V) m/z: [M+H]+, 331.34. HRMS(ESI+): m/z = calcd. for C20H15N2O3 [M+H]+ 331.10772 found:331.10606.
The synthetic route of N-Vinylphthalimide has been constantly updated, and we look forward to future research findings.