Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20870-79-5, name is 5-Nitroindolin-2-one, A new synthetic method of this compound is introduced below., Recommanded Product: 20870-79-5
Description 1:thylene)-5-nitroindolin-2-oneIn a 35 ml microwave tube were placed 5-nttro-1,3-dihydro-2H-indol-2-one (1 mmol), pyrrole-2-carbaldehyde (1.2 mmol), piperidine (2 drops), ethanol (10 mi) and a magnetic stir bar. The vessel was sealed with a septum and placed in the microwave cavity. Initial microwave irradiation of 200 W was used, the temperature being ramped from room temperature (RT) to 150 C. Once 150 C was reached the reaction vessel was held at this temperature for 30 min by moderation of the initial microwave power. After cooling, solvent was removed in vacuo and ethyl acetate was added to the reaction mixture. The precipitate was collected by filtration and washed with ethyl acetate (2x 10 ml) to afford a yellow-brown solid. The NMR results below identify the product as the title compound D1. 1H NMR (DMSO-de) delta = 13.16 (1H, brs), 11.55 (1H, brs), 8.61 (1H, d, J = 2.5 Hz), 8.18 (1H, s), 8.08 (1H, dd, JA = 2.5 Hz, J2 – 2.2 Hz), 7.47 (1H, m), 7.06 (1H, d, J = 8.8 Hz), 6.97 (1H, m), 6.44 (1H, m). 13C NMR (DMSO-de) delta = 169.6, 144.0, 142.1, 129.6 (2C), 127.6, 126.1, 122.8, 122.6, 114.0 (2C), 112.2, 109.4.
The synthetic route of 20870-79-5 has been constantly updated, and we look forward to future research findings.