Electric Literature of 959235-95-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 959235-95-1, name is 6-(Trifluoromethoxy)indoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 2-((3-(4-(fe/t-butoxy)-4-oxobutoxy)-5-nnethoxyphenyl)annino)-2-(2- (2-((fe/t-butyldinnethylsilyl)oxy)ethoxy)-4-chlorophenyl)acetic acid 8d (675 mg, 1.08 mmol) in DMF (6 ml_) were added HATU (617 mg, 1.62 mmol),diisopropylethylamine (536 muIota_, 3.24 mmol) and 6-(trifluoromethoxy)indoline [CAS 959235-95-1] (220 mg, 1.08 mmol). The reaction mixture was stirred at room temperature for 7 days. The reaction mixture was diluted with water. The precipitate was filtered off, washed with water and taken up with EtOAc. The organic layer was washed with a 10% solution of K2CO3 and water, dried over MgSO4, filtered and the solvent was concentrated under reduced pressure to give terf-butyl 4-(3-((1 -(2-(2-((fe/t-butyldimethylsilyl)oxy)ethoxy)-4-chlorophenyl)-2-oxo- 2-(6-(trifluoromethoxy)indolin-1 -yl)ethyl)amino)-5-methoxyphenoxy)butanoate 8e (385 mg). The compound was used without further purification in the next reaction step.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-(Trifluoromethoxy)indoline, other downstream synthetic routes, hurry up and to see.