Related Products of 132898-96-5, These common heterocyclic compound, 132898-96-5, name is 2,3-Dioxoindoline-5-sulfonyl chloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General Procedure: To a solution of 4 (1.32 g, 5 mmol) in CH2Cl2 (10 mL), trifloroacetic acid (10 mL) was added at 0 oC. The mixture was stirred at 0 oC for 15 min. After evaporation of the solvent in vacuo, CH2Cl2 (15 mL) and triethylamine (2 mL) were added, then a solution of 2,3-dioxoindoline-5-sulfonyl chloride (1.23g, 5mmol) in THF (25 mL) was added at 0 oC. The reaction mixture was stirred overnight at rt. Then the solvent was evaporated in vacuo, ethyl acetate (100 mL) was added, washed with water (50 mL x 2), saturated NaCl (50 mL), and dried over Na2SO4. After evaporation of the ethyl acetate, the crude product was purified by Flash column chromatograph with ethyl acetate to afford 1.27 g (68%) of 5.
The synthetic route of 132898-96-5 has been constantly updated, and we look forward to future research findings.