Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6326-79-0, name is 6-Bromoisatin, A new synthetic method of this compound is introduced below., Product Details of 6326-79-0
To a round bottom flask containing 6-bromoindoline-2,3-dione (1 g, 4.42 mrnol) was added NaOH (4.9 mL, 4.87 mmol) and stirred at 50 C for I h. The reaction mixture is then brought to ii and cooled to 0C before adding a solution of NaNO2 (0.31 g, 4.42 mmol) in 1-120 (1 1 mL) dropwise over a period of 15 mins, The above mixture was then added to a solution of H20 (9 mL) and H2S04 (46 mL) thai is precooled to 0 C dropwise over a period of 15 mins. The crude mixture was then added to a mix of cone. HCI (4 mL)and SnC1?.2H20 (2.5 g, 11.06 rnmoi) at ii and continued to stir at rt for I h. The solids are then filtered and dried to give the crude product 6-hromo-IH-indazoie-3-carhoxyiic acid (Intermediate I 12A) (1.1 g, 93%) as a tan solid. The crude product was taken to the next step without further purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.