Application of 435273-55-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 435273-55-5 as follows.
Example 2: Synthesis of 5,6-dimethyldibenzo[crfj/lindol-4(5//)-one; 4-Bromo-2-methylisoindolin-l-one (60 mg, 0.26 mmol) obtained in Step 3 of Example 1, 2-acetylphenylboronic acid (51 mg, 0.32 mmol), tetrakis(triphenylphosphine)palladium (12 mg, 0.01 mmol), 2- (dicyclohexylphosphino)-2′-(N,N-dimethylamino)biphenyl (8 mg, 0.02 mmol) and cesium carbonate (259 mg, 0.80 mmol) were dissolved in a 1 m. of ethanol-2 mNo. toluene mixture and placed in a vessel. The vessel was sealed using a septum, and heated for 5 min at 120C and for 10 min at 150C is a microwave reactor and cooled to room temperature. The reaction mixture was filtered through a cellite column while washing with ethyl acetate, and the solvent was evaporated under a reduced pressure. The resulting residue was subjected to silica gel column chromatography to obtain 5,6- dimethyldibenzoindol-4(5H)-one (52 mg (77%)).1H NMR (300 MHz, CDCl3) delta 8.56-8.53 (m, 2H), 8.08-8.05 (m, 2H), 7.79-7.76 (m, IH), 7.65-7.59 (m, 2H), 3.75 (s, 3H), 2.84 (s, 3H).
According to the analysis of related databases, 435273-55-5, the application of this compound in the production field has become more and more popular.