169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 5-(Trifluoromethoxy)indoline-2,3-dione
Information Example 2: 5-Trifluoromethoxy-1H-indole Lithium aluminum hydride (10.4 mL,1M in THF, 10.4 mmol) was added to a solution of 5-trifluoromethoxyistatin (0.8 g, 3.45 mmol) in THF at room temperature and the mixture was refluxed overnight. The reaction mixture was cooled, and Na2SO4ยท10H2O was added very carefully portionwise, followed by ethyl acetate. The reaction mixture was then filtered, and the filtrate was evaporated. The residual oil was purifed by column chromatography with ethyl acetate in hexanes (2:98) to yield 5-trifluoromethoxy-1H-indole (0.162 g, 23%).
The synthetic route of 169037-23-4 has been constantly updated, and we look forward to future research findings.