These common heterocyclic compound, 264916-06-5, name is tert-Butyl 5-aminoisoindoline-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 264916-06-5
To 517 mg of P14 in 15 ml_ of THF at O0C was added 350 mg of 60% sodium hydride in mineral oil and the mixture stirred for 10 minutes. 570 mg of P15 was then added and the mixture warmed to room temperature. After three days the reaction mixture was quenched with water then extracted three times with ethyl acetate. The combined extracts were washed with brine, dried with magnesium sulfate, filtered and evaporated to dryness. Purification by flash chromatography yielded 450mg of 8. LCMS: 433.2 (MH+)
The synthetic route of tert-Butyl 5-aminoisoindoline-2-carboxylate has been constantly updated, and we look forward to future research findings.