Some common heterocyclic compound, 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 446292-08-6
To the slurry of Formula-4 160 gm, 0.379 moles in 800 ml isopropyl alcohol, Charged 40% methylamine solutionl30 gm, 1.677 moles. Reaction mass was heated up to 45C-50C for 2-3 Hrs. Distilled out IPA under vacuum and charged fresh 800 ml Isopropyl alcohol Cooled reaction mass to 45C-50C and added 70% solution of Perchloric acid 59.6 gm, 0.415 moles. Stirred reaction mass for 1 Hrs at 45-50C. Cooled reaction mass to 0-5 C, filtered and dried at 50C-55C to afford 160 gm crude 4-{4-[(5S)-5-(Aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]-phenyl}-morpholin-3-one perchlorate. The crude 4-{4-[(5S)-5-(Aminomethlyl)-2-oxo-1,3-oxazolidin-3-yl]-phenyl}-mophiholin-3-one perchlorate has a crystalline nature and is in considerably pure form.To Above crude 4-{4-[(5S)-5-(Aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]-phenyl}-morpholin-3-one perchlorate charged 640 ml Dichloromethane (4 vol of starting material) and charged 320 ml methanol. Heated the slurry to 38C – 40C and stirred for 30 min. Cooled the slurry to 20C. Filtered and suck dried. Product obtained after drying was 138.7 gm pure crystalline perchlorate salt having purity more than 99.5% (Yield-94%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 446292-08-6, its application will become more common.