Adding a certain compound to certain chemical reactions, such as: 17630-75-0, name is 5-Chloro-2-oxindole, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17630-75-0, Safety of 5-Chloro-2-oxindole
7-Bromo-5-chloro-2-oxindole 5-Chloro-2-oxindole (16.8 g) and 19.6 g of N-bromosuccinimide were suspended in 140 ML of acetonitrile and refluxed for 3 hours.. Thin layer chromatography (silica, ethyl acetate) at 2 hours of reflux showed 5-chloro-2-oxindole or N-bromosuccinimide (Rf 0.8), product (Rf 0.85) and a second product (Rf 0.9) whose proportions did not change after another hour of ref lux.. The mixture was cooled to 10 C., the precipitate was collected by vacuum filtration, washed with 25 ML of ethanol and sucked dry for 20 minutes in the funnel to give 14.1 g of wet product (56% yield).. The solid was suspended in 200 ML of denatured ethanol and slurry-washed by stirring and refluxing for 10 minutes.. The mixture was cooled in an ice bath to 10 C. The solid product was collected by vacuum filtration, washed with 25 ML of ethanol and dried under vacuum at 40 C. to give 12.7 g (51% yield) of 7-bromo-5-chloro-2-oxindole.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-2-oxindole, and friends who are interested can also refer to it.