Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, This compound has unique chemical properties. The synthetic route is as follows., category: indolines-derivatives
EXAMPLE 12 (E)-1-(2,6-Dichlorophenyl)-3-(4-methyl-benzyli-dene)-1,3-dihydro-2H-indol-2-one 1-(2,6-Dichlorophenyl)-oxindole (22.24 g; 80 mmoles) and 4-methyl benzaldehyde (10.0 g; 84 mmoles) are dissolved in 250 ml of toluene, pyrrolidine (4.0 ml; 0.30 mole) is measured to the solution, and the mixture is warmed to reflux temperature. It is refluxed for 1 hour, allowed to cool, extracted twice with 10% hydrogen chloride, the toluene phase is dried over sodium sulfate, clarified with bone coal, filtered, washed on the filter with toluene and evaporated. The residual orange-red oil gets crystalline upon trituration with hexane. The substance is stirred in hexane, filtered and washed with hexane. The product is used for the catalytic hydrogenation without recrystallization. Yield: 18.59 g of yellow crystal (61%). M.p.: 201-202 C. (ethyl acetate). IR (KBr): 1716 (C=O), 791 cm-1. 1H-NMR (CDCl3, TMS, 400 MHz): 2.44 (3H, s), 6.41 (1H, d, J=7.9 Hz), 6.95 (1H, t, J=7.7 Hz), 7.18 (1H, t, J=7.7 Hz), 7.30 (2H, d, J=8.0 Hz), 7.37 (1H, t, J=7.7 Hz), 7.51 (1H, d, J=7.9 Hz), 7.64 (2H, d, J=8.0 Hz), 7.81 (1H, d, J=7.7 Hz), 7.96 (1H, s) ppm. 13C-NMR (CDCl3, TMS, 101 MHz): 21.6, 109.2, 121.4, 122.4, 123.0, 125.5, 128.9, 129.3, 129.5, 129.6, 130.5, 130.6, 131.8, 135.7, 138.8, 140.2, 142.1, 167.2 ppm. Analysis for the Formula C22H15Cl2NO (380.28): Calculated: C, 69.49; H, 3.98; Cl, 18.65; N, 3.68%. Found: C, 69.53; H, 4.03; Cl, 18.49; N, 3.67%.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15362-40-0.