Synthetic Route of 496-12-8, The chemical industry reduces the impact on the environment during synthesis 496-12-8, name is Isoindoline, I believe this compound will play a more active role in future production and life.
Step 1: Boc-4-Oxo-proline methyl ester (100 mg, 0.41 mmol) and isoindoline (51 pL, 0.43 mmol) were dissolved in DCE (1 .5 mL) and acetic acid (25 pL, 0.41 mmol) added. After 1 hour, NaBH(OAc)3 (261 mg, 1 .23 mmol) was added and the reaction mixture stirred at room temperature overnight. The reaction mixture was diluted with sat. aq. NaHCO3 and extracted with DCM. The combined organics were passed through a phase separator and the solvent removed to give acrude product which was purified by column chromatography (Biotage, 1 Og SNAP, 0-80% EtOAc/ihexane) to give (25,4R)-4-(1 ,3-dihydro-isoindol-2-yl)-pyrrolidine-1 ,2-dicarboxylic acid 1-tert- butyl ester 2-methyl ester (0.1 3g, 92%) as a brown oil.AnalpH2_MeOH_4MIN: Rt: 1.99 mi mlz 347.3 [M+H]+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Isoindoline, other downstream synthetic routes, hurry up and to see.