Electric Literature of 88150-75-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 88150-75-8 as follows.
Ethyl 2- { [2-D, 3-DIOXOISOINDOLIN-2-YDETHOXY] METHYL}-4- (2-CHLOROPHENYL)-5-CYANO-6- methyl-1,4-dihydropyridine-3-carboxylate. A mixture of 2-chlorobenzaldehyde (2.64 g; 18.79 mmol), 3-aminocrotononitrile (1.54 g; 18.79 MMOL), and ethyl 4- [2- (1, 3- dioxoisoindolin-2-yl) ethoxy] -3-oxobutanoate (6 g; 18. 79 mmol) in MeOH is heated to reflux for 6 days. After cooling, the solvent is removed under reduced pressure and the crude product is purified on a silica gel column to obtain the product in 70% yield as a light yellow solid.
According to the analysis of related databases, 88150-75-8, the application of this compound in the production field has become more and more popular.