Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52351-75-4, name is 6-Methoxyindoline-2,3-dione, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C9H7NO3
Example 12 (S)-3,5-Dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)- phenyl)-2-(2-(6-methoxy-2,3-dioxoindolin-1 -yl)acetoxy)ethyl)-pyridine 1 -oxide (Compound 64) Scheme 12 Step 1 : Preparation of tert-butyl 2-(6-methoxy-2,3-dioxoindolin-1 – yl)acetate (62) To a solution of 6-methoxyindoline-2,3-dione (350 mg, 1 .976 mmol) in acetonitrile (10 ml), K2C03 (328 mg, 2.371 mmol) and tert-butyl 2-bromoacetate (350 muIota, 2.371 mmol) were added and the mixture was reacted at room temperature overnight. The insoluble inorganic salts were filtered off and the solvent was evaporated obtaining the crude title compound (550 mg, 1 .888 mmol, 96% yield). MS/ES 292.1 [MH] +. The crude was used in the next step without further purification.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52351-75-4.