Electric Literature of 17702-83-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17702-83-9 as follows.
A mixture of compound 54 (0.85 g, 5.62 mmol), Na2CO3 (0.95 g, 8.99 mmol), and compound 3 (2.16 g, 6.39 mmol) in CH3CN (40 ml) was sirred under reflux for 48 h, cooled, and poured onto ice-water (300 ml). The mixture was extracted with CH2CI2 (3 x 100 ml), the combined extracts were dried (Na2SO4), and concentrated. The residue was purified by column chromatography (petroleum ether-EtOAc (5: 1)) to afford a 2: 1 mixture of the title compound 55 with the starting amine 54 as a colourless oil which was used in the next step without further purification. 1H-NMR (200 MHz, CDCI3, HMDSO): delta 1.15 (t, J=7.1 Hz, 3H); 1.22-1.41 (m, 8H); 1.47-1.76 (m, 4H); 2.74 (q, 3=1.1 Hz, 2H); 3.67 (t, 3=1.1 Hz, 2H); 4.69 (s, 2H); 7.23-7.39 (m, 5H), 7.64-7.75 (m, 2H); 7.78-7.88 (m, 2H).
According to the analysis of related databases, 17702-83-9, the application of this compound in the production field has become more and more popular.