Application of 1504-06-9, The chemical industry reduces the impact on the environment during synthesis 1504-06-9, name is 3-Methyloxindole, I believe this compound will play a more active role in future production and life.
-Methyloxindole (1.5 g, 10.2 mmol) and lithium chloride (1.26 g, 30 mmol) was dissolved in THF (100 mL). The solution was then cooled to -78 C. and n-butyllithium (4.2 mL, 2.5 M in hexanes, 10.5 mmol) was added slowly over a 15 minute period. Ethyl iodide (4.16 mL, 50 mmol) was added and the mixture was allowed to warm to room temperature. After 24 hours, the mixture was poured into water and extracted with ethyl acetate, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography (SiO2, Hexane/ethylacetate 9/1 then 8/2) gave 3-ethyl-3-methyl-1,3-dihydro-2H-indol-2-one (0.750 g, 25%): HRMS [M+H]+176.1076
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methyloxindole, other downstream synthetic routes, hurry up and to see.