Electric Literature of 2058-72-2, These common heterocyclic compound, 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Representative experimental procedure for Phospho-Aldol reaction: In a typical experiment, Catalyst 1h (0.04 mmol) was added to a stirred solution of 1-methylisatin 2a (2.0 mmol) in CH2Cl2 (3 mL) at 0 C under an atmosphere of air. The resulting solution was magnetically stirred for 10 min prior to the addition of pre-cooled (0 C) Diphenyl phosphite 3a (0.40 mmol). After stirring for the indicated reaction time at 0 C (monitored by TLC), the crude adduct 4a was purified by column chromatography (petroleum ether/ethyl acetate, 3:1). The enantiomeric excess of the pure product was determined by chiral HPLC analysis on chiralpak AS-H.
Statistics shows that 5-Bromo-1-methylindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 2058-72-2.