Reference of 366453-21-6,Some common heterocyclic compound, 366453-21-6, name is 4-Hydroxy-2,3-dihydroisoindol-1-one, molecular formula is C8H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
m Synthesis of 2,3-dihydro-1H-isoindol-1-one (32): To a solution of 4-hydroxy isoindolinone 27 (0.100 gm, 0.67 mmol) in methylene chloride (5 ml) and triethylamine (0.2 ml), was added m-nitrobenzoyl chloride (0.125 gm, 0.67 mmol) at 0 C., and the reaction mixture was stirred at room temperature for 5 hr. After the usual workup, the resulting residue was purified by PTLC plate (solvent was 10% methanol-methylene chloride) to give 2,3-dihydro-1H-isoindol-1-one 32 (0.025 mg, 28%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Hydroxy-2,3-dihydroisoindol-1-one, its application will become more common.