Electric Literature of 60434-13-1, A common heterocyclic compound, 60434-13-1, name is 5-Chloro-1-methylindoline-2,3-dione, molecular formula is C9H6ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of ethyl acetoacetate (1 mmol) and hydrazinehydrate (1 mmol) was stirred for 5 min at room temperature.Then water (5 mL), isatin (1mmol), malononitrile (1 mmol)were added sequentially to the resulting mixture and stirredcontinuously for the time as indicated in Table 1. The progressof the reaction was monitored by TLC. After completionof reaction, the precipitated product was filtered andwashed with water and cold ethanol to afford correspondingspiro[indoline-3,4?-pyrano[2,3-c]pyrazoles.
The synthetic route of 60434-13-1 has been constantly updated, and we look forward to future research findings.