959235-95-1, name is 6-(Trifluoromethoxy)indoline, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 6-(Trifluoromethoxy)indoline
To a solution of 2-(2-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-4-fluorophenyl)-2-((3- methoxy-5-(methylsulfonyl)phenyl)amino)acetic acid 2d (1 g, 1 .90 mmol) in DMF (10 mL) were added HATU (1 .08 g, 2.84 mmol), diisopropylethylamine (940 pL,5.69 mmol) and 6-(trifluoromethoxy)indoline [CAS 959235-95-1] (385 mg, 1.90 mmol). The reaction mixture was stirred at room temperature for 4 h. The reaction mixture was diluted with water. The precipitate was filtered off, washed with water and taken up with EtOAc. The organic layer was washed with a 10% solution of K2003 in water, a saturated solution of NaCI in water, water, dried over MgSO4,filtered and the solvent was concentrated under reduced pressure to give 2-(2-(2-((tert-butyld imethyl silyl )oxy)ethoxy)-4-fl uorophenyl )-2-((3-methoxy-5-(methylsulfonyl)phenyl)amino)-1 -(6-(trifluoromethoxy)indolin-1 -yl)ethanone 3a(1 .32 g). The crude compound was used without purification in the next reactionstep.
The synthetic route of 959235-95-1 has been constantly updated, and we look forward to future research findings.