Application of 65826-95-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 65826-95-1, name is 5-Methylindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
In the dried Schrank tube, raw porphyrin (0.15 mmol, 26.2 mg), p-toluenesulfonamide (0.3 mmol, 51.1 mg), iodobenzene acetate were added in sequence.(0.15 mmol, 48.3 mg), pentamethylcyclopentadienylphosphonium dichloride (5 mmol%, 4.6 mg), silver triflate (20 mmol%, 7.7 mg),Silver acetate (20 mmol%, 5.1 mg), acetic acid (0.45 mmol, 27 mg)1.5 mL of 1,2-dichloroethane, and the above-mentioned Schalke tube was placed in a 100 o C oil bath.Stir for about 16 h. Stop the reaction,The reaction solution is easily quenched using 2 mL of saturated ammonium chloride.After further extraction with ethyl acetate (4 mL × 5), the organic phases were combined.The solvent was removed on a rotary evaporator. Finally, separation by silica gel column chromatography(eluent: ethyl acetate: petroleum ether = 1: 5),Obtaining N-(1-acetyl-5-methylporphyrin-7-yl)-4-methylbenzenesulfonamide 3e(46.4 mg, isolated yield: 90%).This compound was a pale yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methylindoline, other downstream synthetic routes, hurry up and to see.