Reference of 39755-95-8,Some common heterocyclic compound, 39755-95-8, name is 5-Methoxyisatin, molecular formula is C9H7NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under air conditions,Add pressure tube to each open5-methylisatin (0.5 mmol, 88.5 mg),Cu (OAc) 2 (1.25 mmol, 249.5 mg), and then 2 mL of DMSO was added to the reaction tube. The mixture was stirred in an oil bath at 120 C under magnetic stirring.TLC followed the reaction. Reaction 14h.Cooling stand, the reaction solution was diluted with 5mL CH2Cl2, 30mL water and 2 ~ 3mL ammonia, liquid separation. The aqueous phase was further extracted with CH 2 Cl 2 (3 × 10 mL) and the organic phases were combined,Dry over anhydrous Na2SO4, filter and evaporate the solvent under reduced pressure.Column chromatography EA: PE = 1: 4 yielded 31.3 mg of a yellow solid in 32.8% yield.
The synthetic route of 39755-95-8 has been constantly updated, and we look forward to future research findings.