317-20-4, name is 7-Fluoroisatin, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H4FNO2
Is added to the reactor 198 mg (1.2 mmol) 7 – fluoro – isatin and 144.1 mg (1.44 mmol) 2, 4 – pentanedionato, add 50 ml tetrahydrofuran and 5 ml DMF as the reaction solvent, adding 1 ml H2O2And 14.5 mg ZnCl2As the catalyst, the electric jacket is heated to 85 C, magnetic stirring reflux reaction for 12 hours. Thin-layer chromatographic trace to after the reaction is complete, evaporating the solvent under reduced pressure, the filter cake is tetrahydrofuran washing, drying to obtain the target compound 175.5 mg, total yield 59.2%.
The synthetic route of 317-20-4 has been constantly updated, and we look forward to future research findings.