Related Products of 41910-64-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41910-64-9, name is 4-Chloroindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Initially a 2.5 dram reaction vial was charged with 60% sodium hydride (0.028 g, 0.700 mmol) and salicylamide (0.072 g, 0.525 mmol) in DMF (2 mL).The mixture was allowed to stir at room temperature for 1 hour.4-Chloro-6-ethoxy-2- (pyridin-3-yl) quinazoline (0.100 g, 0.350 mmol) was then added to the mixture and the reaction was allowed to proceed overnight at room temperature.LC-MS analysis of the crude mixture showed that the formed product was about 85% and 10% remained as starting material. Water (30 mL) was added to the mixture and the product was extracted with chloroform (3 × 15 mL). The combined organic layers were dried (Na 2 SO 4), filtered and concentrated. The crude product was purified by ISCO (silica gel, 97.5: 2.5 CH2 Cl2 / MeOH; 12 g column) to afford 13.9 mg of the desired product as a white solid (10.3%).
The synthetic route of 4-Chloroindoline has been constantly updated, and we look forward to future research findings.