Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 141452-01-9, name is Methyl indoline-5-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C10H11NO2
Under the protection of argon, dissolve bis (trichloromethyl) carbonate (296mg, 1mmol) in 5mL of tetrahydrofuran, cool to 0 C, add triethylamine (202mg, 2mmol), stir for 5 minutes, and add indoline- Methyl 5-carboxylate 3a (177 mg, 1 mmol, prepared according to the published patent application “WO 2010149685”) was reacted at room temperature overnight. 20 mL of 2N dilute hydrochloric acid was added and extracted with dichloromethane (30 mL × 3). The organic phases were combined, washed with a saturated sodium bicarbonate solution (30 mL) and a saturated sodium chloride solution (30 mL), and the organic phase was dried over anhydrous sodium sulfate. , Filtered, and concentrated under reduced pressure to give 1- (chlorocarbonyl) indololine-5-carboxylic acid methyl ester 3b (239 mg, white solid), yield: 100%.
According to the analysis of related databases, 141452-01-9, the application of this compound in the production field has become more and more popular.