Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50727-04-3, name is 5-Methoxyisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Formula: C9H7NO3
To a suspension of D23 (6.14 g, 35 [MMOL)] in dry tetrahydrofuran (25 mL) was added dropwise BH3-THF (100 mL, 1M in tetrahydrofuran) then heated at reflux overnight. The mixture was cooled to [0C] then quenched by dropwise addition of methanol (10 mL). After stirring at room temperature for 20 minutes 5M HCI (10 [ML)] was added and the mixture heated at reflux for 1 hour. The mixture was cooled to room temperature, the pH adjusted to pH 10 by the addition of 2M [NAOH] (58 mL) and extracted with dichloromethane. The organic layer was dried [(MGS04),] and evaporated. Purification by SCX followed by evaporation gave the title compound D24 as an oil (1.76 g). [MH+] 150.’H NMR [8] (CDCI3) 3.80 (3H, s), 4.17 (2H, s), 4.20 (2H, s), 6.75-6. 83 (2H, m), 7.13 [(1H,] d).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.