Application of 6344-05-4, These common heterocyclic compound, 6344-05-4, name is 4-Chloroisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To the 25 ml dry round-bottom flask is added in 3 ml toluene, 163 mg (1mmol) isatoic anhydride, 181 mg (1mmol) 4- chloroisatin (purchased from Shanghai the nation becomes chemical Company limited), 505 mg (5mmol) triethylamine, then heating to 110 °C, stir at reflux reaction 3-4h, TLC detection display after the reaction is finished, pressure reducing evaporate solvent, residue is recrystallized in ethanol, to obtain the product 7- chlorine tryptamine alkone 225 mg, yield 80percent.
The synthetic route of 6344-05-4 has been constantly updated, and we look forward to future research findings.