Synthetic Route of 200049-46-3, The chemical industry reduces the impact on the environment during synthesis 200049-46-3, name is 7-Bromo-2,3-dihydro-isoindol-1-one, I believe this compound will play a more active role in future production and life.
Similar to the procedure used to prepare Compound 32, Compound Ic was reacted with Compound 12a and Pd(OAc)2, P(?-tolyl)3, and 2N aqueous Na2CO3 in DMF to give Compound 23 as a clear, colorless oil. 1H NMR (400 MHz, CDCl3) 1.30 and 1.65 (rotamer A and B, two singlets, 9H), 4.42 (s, 2H), 6.25 (m, IH), 7.35-7.65 (complex, 5H); MS (ESI) m/z: 299 (MH+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromo-2,3-dihydro-isoindol-1-one, other downstream synthetic routes, hurry up and to see.