Reference of 954-81-4, A common heterocyclic compound, 954-81-4, name is N-(5-Bromopentyl)phthalimide, molecular formula is C13H14BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a suspension of compound 9-12 (20 mmol) and potassium carbonate (50 mmol) in ACN (150 mL) was added dropwise the secondary amine (4 eq.) and the reaction mixture was refluxed for 24 h. After cooling, the reaction mixture was filtered and the filtrate was concentrated to afford an oil that was directly engaged in the next step without further purification. Reactions were performed on a scale of 5 to 20 g of compounds 9-12 to afford amines 14 and 15 with the following yields: 14a, Yield 90%; 14b, Yield 93%; 15a, Yield 89%; 15b, quantitative yield; 15c, Yield 35%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.