317-20-4, name is 7-Fluoroisatin, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: indolines-derivatives
Preparation 5. Synthesis of 8-F-4-CO2H-quinoline: To a solution of 7-fluoroisatin (500 mg, 3.03 mmol) in water (10 mL) at the room temperature were added aqueous NaOH solution (2.5 mL, SM, 12.5 mmol) and sodium pyruvate (400 mg, 3.66 mmol), and it?s then placed in a microwavereactor (CEM discover 5) at 110C for 10 mm. The resulting solution was cooled down and acidified to pH 2, and the dark solid was then collected. A suspension ofsolid in water (2 mL) was then placed in a 10 mL microwave tube followed by stirring at 170C (or 280 psi) in a microwave reactor for 5 mm. The desired product (brown solid, 340 mg, 60% yield) was then filtered off and collected. LRMS (M+Hj m/z: cacld 192.04, found 192.16.
The synthetic route of 317-20-4 has been constantly updated, and we look forward to future research findings.