Adding a certain compound to certain chemical reactions, such as: 6326-79-0, name is 6-Bromoisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6326-79-0, Quality Control of 6-Bromoisatin
6-Bromo-1H-indole-2,3-dione is treated with sodiumhydroxide (1.1 eq) in water at 30C till all solids are dissolved. Sodiumnitrite (1.1 eq) dissolved in a little amount of water is added slowly at this temperature and the solution is stirred for additional 30 minutes. The mixture is slowly added to a solution of sulfuric acid (1.9 eq) in water at 0C keeping the internal temperature below 10C. After additional 20 minutes at this temperature, a mixture of tin(ll)chloride (2.4 eq) in water and hydrochloric acid is added slowly. After 2h of stirring at 0C workup by filtration over celite, washing with acetone and removing the solvent in vacuum gives the intermediate carboxylic acid. 6-Bromo-1H-indazole-3-carboxylic acid is converted into the corresponding methylester following standard procedures.
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