In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99365-40-9, name is 6-Bromoindolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: indolines-derivatives
Compound 2 (2.1g, 10mmol), 6- bromo-indole (5.6g, 11mmol), glacial acetic acid (60ml) was addedThe two bottles, 3 drops of hydrochloric acid was added dropwise, under a nitrogen atmosphere, 130 refluxed for 24h, cooled to room temperature, adding a lot of water,Extracted with methylene chloride three times, the combined organic phase was washed with saturated sodium chloride, dried over anhydrous MgSO4, spin dry solvent,Petroleum ether: methylene chloride 1:1 (by volume) as eluent, column separation, spin dry to give a brown flaky solid(6.46g, 92%).
The synthetic route of 99365-40-9 has been constantly updated, and we look forward to future research findings.