In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 446292-08-6 as follows. Formula: C22H19N3O6
4- [4-((S)-5-aminomethyl]-2-oxooxazolidin-3-yl)phenyl]morpholine-3-one (VII) 100 gm (wet) (0.2375 moles) 2-({(5S)-2-Oxo-3-[4-{3-oxo-4-morpholmyl)phenyl]- l,3- oxazolidin-5-yl}methyl)- lH-isoindole- l,3(2H)-dione (VI) is added in 500 ml water and (46.02 gm, 1,4845 moles) methyl amine solution (40% Aqueous). Reaction mass is stirred at 35C for 5 hours to get 4-[4-((S)-5-aminomethyl]-2-oxooxazolidin-3-yl) phenyl]morpholine-3-one (VII). Reaction mass is subjected for degassing (i. e. kept under vacuum) for 1 hour to remove excess methyl amine. This aqueous reaction mass is used as such for the preparation of Rivaroxaban without isolation.
According to the analysis of related databases, 446292-08-6, the application of this compound in the production field has become more and more popular.