Synthetic Route of 15861-23-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15861-23-1 name is Indoline-5-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The 5 – cyano – indoline (0.14 g, 1. 00 mmol) is added to dichloromethane (6 ml) in, adding pyridine (0.24 g, 3. 00 mmol) and intermediate 6 a (0.27 g, 1.000 mmol), Canada finishes after stirring at room temperature 1 hour. Concentrated under reduced pressure the crude intermediate 6 b directly used for the next step reaction.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Indoline-5-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Chengdu Xiandao Pharmaceutical Development Co., Ltd.; Li Jin; Wang Wei; Chu Hongzhu; Lv Kaizhi; Liu Lichuan; Nong Yunhong; Chen Wei; (17 pag.)CN110256416; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem