Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1498-88-0, name is 1′,3′,3′-Trimethyl-6-nitrospiro[chromene-2,2′-indoline], A new synthetic method of this compound is introduced below., Quality Control of 1′,3′,3′-Trimethyl-6-nitrospiro[chromene-2,2′-indoline]
1,3,3-Trimethyl-60-nitrospiro[chromene-2,20-indoline] (6.45 g,20 mmol) and SnCl2 (18.96 g, 0.10 mol) were added to a flask underN2 atmosphere. Anhydrous ethanol (100 mL) was added and thereaction mixture was heated to reflux for 2 h. After reaction themixture was cooled to room temperature and filtered. The filtratewas concentrated and 5% aqueous NaOH was added to the residue.The organic phase was extracted with dichloromethane for threetimes,washed withwater and dried. After filtration the solvent wasremoved by evaporation and the residue was purified by columnchromatography with petroleum ether/ethyl acetate (3:1, v/v) aseluent to give the reduction product 1,3,3-trimethyl-60-aminospiro[chromene-2,20-indoline] (3.18 g) as brown solid in 54% yield. Mp139e140 C. 1H NMR (400 MHz, CDCl3) d 7.16e7.14 (m, 1H), 7.05 (d,J 8.3 Hz, 1H), 6.81e6.79 (m, 1H), 6.74 (d, J 8.8 Hz, 1H), 6.55e6.44(m, 3H), 6.41 (d, J 7.9 Hz, 1H), 5.67 (d, J 10.9 Hz, 1H), 2.85 (s, 3H),1.45 (s, 3H), 1.30 (s, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zhang, Ruiqing; Hu, Luping; Xu, Zhenxiang; Song, Yanxi; Li, Hongqi; Zhang, Xin; Gao, Xucheng; Wang, Mengxuan; Xian, Chunying; Journal of Molecular Structure; vol. 1204; (2020);,
Indoline – Wikipedia,
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