In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 239463-85-5 as follows. Recommanded Product: (R)-3-(5-(2-Aminopropyl)-7-cyanoindolin-1-yl)propyl benzoate (2R,3R)-2,3-dihydroxysuccinate
Example 10: Preparation of 5-((R)-2-aminopropyl)-l-(3-hydroxypropyl) indoline- 7-carbonitrile of Formula ICTo a mixture of Tartrate salt of 3-(5-((R)-2-aminopropyl)-7-cyanoindolin-l-yl) propyl benzoate of Formula (I) (5 gm) in methanol (50 ml) and water (50 ml) was added potassium hydroxide and stirred the reaction mass for overnight at room temperature. The mixture was concentrated under reduced pressure and water (100 ml) was added. The mixture was extracted three times with 5% of Methanol: Methylene Dichloride (3 x 100 ml) and the combined organic layers were distilled to give 1.7 gm of 5-((R)-2- aminopropyl)- 1 -(3 -hydroxypropyl)indoline-7-carbonitrile of Formula IC.
According to the analysis of related databases, 239463-85-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PANACEA BIOTEC LTD; JAIN, Rajesh; RAO, Jagadeeshwar R; RAO, Siripragada Mahender; WO2012/131710; (2012); A2;,
Indoline – Wikipedia,
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