Reference of 56341-37-8, These common heterocyclic compound, 56341-37-8, name is 6-Chlorooxindole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl] ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one: (i) Preparation of 6-chloro-5-(chloroacetyl)oxindole : charge 250 ml of methylene dichloride and 100 gm of 6-chloro-oxindole in a 3 litre three neck flask under nitrogen atmosphere at 25 to 30C. Cool gradually to 0 to 5C under stirring and charge 199 gm of anhydrous aluminium chloride in portions at 0 to [50c] and stir for 15 min at 0 to 5C. Add 87.6 gm of chloroacetyl chloride slowly at 0 to 5C over 30 mins. Stir at 0 to 5C for 30 mins. Heat the reaction mixture slowly to reflux (40 to 45C)] over 30 mins. Reflux for 12 hrs. On completion of reaction cool the reaction mixture to 25 to 30C, pour into 1 kg ice, 50 ml of conc. HCl and 450 ml of demin water at 0 to 10C under stirring over 30 mins. Stir for 30 mins, filter solid product and wash with demin water. Prepare a slurry of the solids in hexane and suck dry the product. Dry the product at 70 to 75C.
The synthetic route of 56341-37-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUN PHARMACEUTICAL INDUSTRIES LIMITED; WO2003/99198; (2003); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem