Synthetic Route of 6326-79-0,Some common heterocyclic compound, 6326-79-0, name is 6-Bromoisatin, molecular formula is C8H4BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A chilled (O 0C) aqueous solution of NaNO2 (6.1 g, 88.5 mmol, 27 mL of water) was added to a chilled (0 “C) solution of commercially available compound HI (20 g, 88.5 mmol) in aqueous NaOH (96 mL, 96 mmol, 1 N). The combined solutions were added slowly to chilled aqueous H2SO4 (9.2 mL of cone. H2SO4, 80 mL of water) by means of an addition funnel with the tip below the surface of the acid solution Ice was added to the reaction to maintain 0 ‘C and ether was added to control foaming, as needed. After stirring an additional 10 min, the diazonium solution was added slowly to a chilled mixture of SnCI2-2H2O (50 g, 221 mmol) in concentrated HCI (80 mL) by means of an addition funnel with the tip below the surface of the acid solution. Ice was added to the reaction to maintain 0 C and ether was added to control foaming, as needed. After stirring an additional hour at 0 C, the reaction mixture was stirred at room temperature overnight. Filtered, the golden yellow powder was dissolved in aqueous NaOH, washed with ether, precipitated with aqueous HCI, filtered, and dried to give 20 g of crude compound H2 as yellow powder used into the following reaction without the further purification.
The synthetic route of 6326-79-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHENEX PHARMACEUTICALS AG; KREMOSER, Claus; ABEL, Ulrich; STEENECK, Christoph; KINZEL, Olaf; WO2011/20615; (2011); A1;,
Indoline – Wikipedia,
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