These common heterocyclic compound, 110568-64-4, name is 6-Nitroisoindolin-1-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H6N2O3
6-Nitro-2,3-dihydroisoindol-1-one (4.7 g, 26 mmol) was dissolved in acetic acid (130 ml) and hydrogenated at 50 psi (3 bar) in the presence of palladium on charcoal (0.47 g) overnight. The catalyst was filtered off through a pad of Hyflo and the acetic acid was removed in vacuo. The residue was triturated with dichloromethane/hexane and the resulting solid was filtered off to afford the title compound (3.56 g, 91%). 1H NMR (360 MHz, d6 DMSO) X 8.28 (1H, s), 7.17 (1H, d, J=8 Hz), 6.82 (1H, s), 6.78 (1H, dd, J=8.1, 1.8 Hz), 5.25 (2H, s), 4.16 (2H, s). m/z (ES+) 149 (M+H)+.
The synthetic route of 6-Nitroisoindolin-1-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Boase, Amanda Louise; Ladduwahetty, Tamara; MacLeod, Angus Murray; Merchant, Kevin John; US2004/58970; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem