Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35197-64-9, name is 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Bromo-4-(1,3-dioxoisoindolin-2-yl)butanoic acid
Ethyl 2-bromo-4-(1,3-dioxoisoindolin-2-yl)butanoate (17, n=2):5 Thionyl chloride (3.1 mL, 4-5 eq) was dissolved in CCl4. Then Pht-GABA (2.4 g, 10.3 mmol) was added. The slurry was put on oil bath at ~85 oC and refluxed for 1 h 15 min. Everything dissolved within a few minutes. NBS (1.2 eq., 12.36 mmol, 2.2 g) was added to the warm solution forming yellow slurry. On addition of 3 drops of 40% HBr(aq) everything dissolved and solution became red. Reaction mixture was heated under reflux. Within 1 h of reflux in homogenous mixture turned black. After additional 10 min reaction mixture was cooled down, poured into 15 mL of dry EtOH (exothermic), followed by addition of EtOH (2×15 mL). After 10 min it was evaporated to dryness. Product isolated using column chromatography
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 35197-64-9.
Reference:
Article; Coxon, Fraser; Joachimiak, ?ukasz; Najumudeen, Arafath Kaja; Breen, George; Gmach, Joanna; Oetken-Lindholm, Christina; Way, Rebecca; Dunford, James; Abankwa, Daniel; B?azewska, Katarzyna M.; European Journal of Medicinal Chemistry; vol. 84; (2014); p. 77 – 89;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem