Adding a certain compound to certain chemical reactions, such as: 2913-97-5, name is N-(2-Oxoethyl)phthalimide, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2913-97-5, Computed Properties of C10H7NO3
A solution of ammonium acetate (5.40 g) in methanol (50 ml) was added to a solution of Compound 204 (2.00 g) and (1,3-dioxo-1,3-dihydroindol-2-yl) acetaldehyde (2.00 g) in tetrahydrofuran (70 ml), and the mixture was stirred for 3.5 hours at room temperature. The reaction solution to which a saturated aqueous solution of sodium hydrogen carbonate was added was neutralized, and then extracted three times with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated off. The residue was purified by silica gel column chromatography three times with (hexane:ethyl acetate=40:60 –> 20:80), (chloroform:methanol=95:5), and (chloroform:ethyl acetate=35:65) to yield the title compound (1.90 g) as a light yellow powder (mp: 250.5-255.0¡ãC). 1H NMR (300 MHz, CDCl3) delta ppm: 2.44 (3H, d, J = 0.8 Hz), 5.08 (2H, s), 6.74 (1H, brs), 7.71-7.94 (6H, m), 8.16 (1H, d, J = 8.5 Hz), 9.03 (1H, s)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-(2-Oxoethyl)phthalimide, and friends who are interested can also refer to it.
Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD; EP1721905; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem