17702-83-9, name is 2-(8-Bromooctyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2-(8-Bromooctyl)isoindoline-1,3-dione
2-(8-(6-Amino-8-((6-iodobenzo[d][1,3]dioxol-5-yl)thio)-9H-purin-9-yl)octyl)isoindoline-1,3-dione (16c) (Scheme 4). 200 mg (0.484 mmol) of Compound 11 was dissolved in DMF (8 mL). 466 mg (1.43 mmol) of Cs2CO3 and 819 mg (2.42 mmol) N-(8-bromooctyl)phthalimide were added and the mixture was sonicated for 1.5 h. Solvent was removed under reduced pressure and the resulting residue was purified by preparatory TLC (CH2Cl2:MeOH:AcOH, 15:1:0.5) to give 120 mg (34percent) of Compound 16c. 1H NMR (500 MHz, CDCl3) delta 8.29 (s, 1H), 7.84 (dd, J = 5.5, 3.1 Hz, 2H), 7.70 (dd, J = 5.5, 3.1 Hz, 2H), 7.28 (s, 1H), 6.87 (s, 1H), 6.29 (br s, 2H), 5.96 (s, 2H), 4.18 (t, J = 7.5 Hz, 2H), 3.67 (t, J = 7.3 Hz, 2H), 1.62-1.77 (m, 4H), 1.25-1.36 (m, 8H); MS (ESI) m/z 671.3 [M+H]+.
The synthetic route of 17702-83-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sloan Kettering Institute For Cancer Research; Cornell University; CHIOSIS, Gabriela; PILLARSETTY, Nagavarakishore; LEWIS, Jason S.; LARSON, Steven M.; TALDONE, Tony; ALPAUGH, Mary L.; (168 pag.)EP3208615; (2017); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem