Some common heterocyclic compound, 84378-94-9, name is 4-Chloro-5-fluoroindoline-2,3-dione, molecular formula is C8H3ClFNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-Chloro-5-fluoroindoline-2,3-dione
2.00 g of 4-chloro-5-fluoroindole quinone was placed in 100 ml three-necked flask, 40 ml of toluene and 1.08 g of potassium borohydride were added in portions. The reaction was as follows: stirring and refluxing, reaction time: 5. Oh , The reaction temperature: 40 C, after the completion of the reaction, the solvent was removed by rotary evaporation to give 0.93 g of crude product of purple solid 4-C1-5-F-4 ‘-Cl-5’ -F-indirubin, The Ethanol was recrystallized to give a purple solid product, m.p.> 30 (TC (thermometer untreated).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 84378-94-9, its application will become more common.
Reference:
Patent; Northwest University; Wang, Culing; Liu, Jianli; Zhao, Danqing; Liu, Zhulan; Zhang, Ning; (10 pag.)CN103980182; (2016); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem