In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 324-03-8 as follows. Quality Control of 6-Fluoroindoline-2,3-dione
A solution of 6-fluoroindoline-2,3-dione (1 g, 6.06 mmol, SCRC) in anhydrous N,N-dimethylformamide (40 mL) was cooled to 00 C, whereupon NaH (60 % dispersion in mineral oil, 0.283 g, 7.09 mmol) was added in one portion and the reaction was stirred for 5minutes. lodomethane (0.443 mL, 7.09 mmol) was added and the reaction was stirred at 0 C for 30 minutes. The mixture was then poured into saturated aqueous NH4C1 and extracted with ethyl acetate. The combined organic portions were washed with water and brine, dried (Mg504), filtered, and concentrated to give the crude product (1.2 g, 88 % purity), which was used without further purification.
According to the analysis of related databases, 324-03-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; HARDEE, David; BREWER, Jason; HASVOLD, Lisa; LIU, Dachun; MCDANIEL, Keith; SCHRIMPF, Michael; SHEPPARD, George; (139 pag.)WO2018/188047; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem