Reference of 59-48-3, These common heterocyclic compound, 59-48-3, name is Indolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Oxindole (2.50g, 19mmol, 1eq.) was dissolved in 80mL of boiling water. Bromine (3 g,19mmol, 1eq.) and potassium bromide (4.50g, 38mmol, 2eq.) were dissolved in 10mL ofwater and then added dropwise to a warm, stired solution of oxindole in 5 min. A whiteprepcipitate appeared. The mixture was stored for 20min in refrigerator. The precipitate wasfiltered, extensively washed with water and dried in vacuum at elevated temperature to give2.70g of 5-bromo-oxindole as a colorless solid.
Statistics shows that Indolin-2-one is playing an increasingly important role. we look forward to future research findings about 59-48-3.
Reference:
Article; Tang, Lin; Peng, Tao; Wang, Gang; Wen, Xiaoxue; Sun, Yunbo; Zhang, Shouguo; Liu, Shuchen; Wang, Lin; Molecules; vol. 22; 11; (2017);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem